HRV & Stress

Research on stress response, anxiety, and mental load

Cell Reports Medicine 2023 Evidence: Works

Cyclic Sighing Outperforms Box Breathing for Stress Reduction

Stanford researchers compared 5-minute daily breathing exercises over 4 weeks. Cyclic sighing (long exhale pattern) improved HRV and reduced anxiety more than box breathing or mindfulness meditation.

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Applied Psychophysiology and Biofeedback 2025 Evidence: Works

HRV Biofeedback Shows Medium Effect Size for Depression

Meta-analysis of HRV biofeedback interventions found consistent improvements in both HRV metrics and depression symptoms, with effects comparable to other evidence-based psychological interventions.

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Translational Psychiatry 2025 Evidence: Works

HRV Reduced Across Most Mental Health Conditions

Umbrella review of meta-analyses confirmed that HRV is reduced in most mental disorders compared to healthy controls, with the strongest evidence for depression and anxiety disorders.

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Applied Psychophysiology and Biofeedback 2025 Evidence: Works

Remote HRV Biofeedback Effective for Depression and Anxiety

Meta-analysis of remote HRV biofeedback interventions found medium effect sizes for improving depression, anxiety, and stress symptoms, supporting app-based biofeedback as accessible mental health intervention.

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Scientific Reports 2025 Evidence: Mixed

Mindfulness Breathing Reduces Stress but May Not Immediately Boost HRV

Study using HRV and eye-tracking found mindfulness breathing significantly reduced perceived stress and improved cognitive flexibility, but did not show immediate HRV improvements in a single session.

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Psychophysiology 2024 Evidence: Works

HRV Shows Promise as Anxiety Treatment Response Biomarker

Review evaluated HRV as a potential biomarker for anxiety disorders, finding that HRV changes track with treatment response and may help predict who will benefit from specific interventions.

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